Evolution of the catalytic mechanism at the dawn of the Baeyer-Villiger monooxygenases

Summary: Enzymes are crucial for the emergence and sustenance of life on earth. How they became catalytically active during their evolution is still an open question. Two opposite explanations are plausible: acquiring a mechanism in a series of discrete steps or all at once in a single evolutionary...

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Bibliographic Details
Main Authors: Guang Yang, Ognjen Pećanac, Hein J. Wijma, Henriëtte J. Rozeboom, Gonzalo de Gonzalo, Marco W. Fraaije, Maria Laura Mascotti
Format: Article
Language:English
Published: Elsevier 2024-05-01
Series:Cell Reports
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124724004583