Improving the Antimycobacterial Drug Clofazimine through Formation of Organic Salts by Combination with Fluoroquinolones

Improving the Antimycobacterial Drug Clofazimine through Formation of Organic Salts by Combination with Fluoroquinolones

This work reports the synthesis, structural and thermal analysis, and in vitro evaluation of the antimicrobial activity of two new organic salts (OSs) derived from the antimycobacterial drug clofazimine and the fluoroquinolones ofloxacin or norfloxacin. Organic salts derived from active pharmaceutic...

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Bibliographic Details
Main Authors: Clara M. Bento, Ana Teresa Silva, Bruno Mansano, Luísa Aguiar, Cátia Teixeira, Maria Salomé Gomes, Paula Gomes, Tânia Silva, Ricardo Ferraz
Format: Article
Language:English
Published: MDPI AG 2023-01-01
Series:International Journal of Molecular Sciences
Subjects:
antibiotics
GUMBOS
ionic liquids
<i>Mycobacterium</i>
organic salts
repurposing
Online Access:https://www.mdpi.com/1422-0067/24/2/1402

Internet

https://www.mdpi.com/1422-0067/24/2/1402

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