Impaired protective role of HLA-B*57:01/58:01 in HIV-1 CRF01_AE infection: a cohort study in Vietnam

Impaired protective role of HLA-B*57:01/58:01 in HIV-1 CRF01_AE infection: a cohort study in Vietnam

Objectives: Human Leukocyte Antigen HLA-B*57:01 and B*58:01 are considered anti-HIV-1 protective alleles. HLA-B*57:01/58:01-restricted HIV-1 Gag TW10 (TSTLQEQIGW, Gag residues 240-249) epitope-specific CD8+ T cell responses that frequently select for a Gag escape mutation, T242N, with viral fitness...

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Bibliographic Details
Main Authors: Tam Tran Thi Minh, Yuta Hikichi, Shoji Miki, Yuriko Imanari, Shigeru Kusagawa, Midori Okazaki, Thao Dang Thi Thu, Teiichiro Shiino, Saori Matsuoka, Hiroyuki Yamamoto, Jun Ohashi, William W. Hall, Tetsuro Matano, Lan Anh Nguyen Thi, Ai Kawana-Tachikawa
Format: Article
Language:English
Published: Elsevier 2023-03-01
Series:International Journal of Infectious Diseases
Subjects:
Human Immunodeficiency Virus type-1
Human Leukocyte Antigen
Escape mutation, Viral fitness
Online Access:http://www.sciencedirect.com/science/article/pii/S1201971222006531

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http://www.sciencedirect.com/science/article/pii/S1201971222006531

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