Highly mutated antibodies capable of neutralizing N276 glycan-deficient HIV after a single immunization with an Env trimer

Highly mutated antibodies capable of neutralizing N276 glycan-deficient HIV after a single immunization with an Env trimer

Summary: Elicitation of HIV broadly neutralizing antibodies (bnAbs) is challenging because unmutated bnAb precursors are rare and seldom bind HIV envelope glycoprotein (Env) trimers. One strategy to initiate bnAb responses is to use germline-targeting (GT) immunogens with high affinity to bnAb-class...

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Bibliographic Details
Main Authors: Jeong Hyun Lee, Catherine Nakao, Michael Appel, Amber Le, Elise Landais, Oleksandr Kalyuzhniy, Xiaozhen Hu, Alessia Liguori, Tina-Marie Mullen, Bettina Groschel, Robert K. Abbott, Devin Sok, William R. Schief, Shane Crotty
Format: Article
Language:English
Published: Elsevier 2022-03-01
Series:Cell Reports
Subjects:
human immunodeficiency virus
germline-targeting vaccine
envelope trimer
broadly neutralizing antibody
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124722002182

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http://www.sciencedirect.com/science/article/pii/S2211124722002182

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