Association between <i>MGMT</i> Enhancer Methylation and <i>MGMT</i> Promoter Methylation, MGMT Protein Expression, and Overall Survival in Glioblastoma

Association between <i>MGMT</i> Enhancer Methylation and <i>MGMT</i> Promoter Methylation, MGMT Protein Expression, and Overall Survival in Glioblastoma

The repair protein O6-methylguanine-DNA methyltransferase (MGMT) is regulated epigenetically, mainly by the methylation of the <i>MGMT</i> promoter. <i>MGMT</i> promoter methylation status has emerged as a prognostic and predictive biomarker for patients with newly diagnosed...

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Bibliographic Details
Main Authors: Katja Zappe, Katharina Pühringer, Simon Pflug, Daniel Berger, Andreas Böhm, Sabine Spiegl-Kreinecker, Margit Cichna-Markl
Format: Article
Language:English
Published: MDPI AG 2023-06-01
Series:Cells
Subjects:
glioblastoma
MGMT
overall survival
prognostic biomarker
enhancer
DNA methylation
Online Access:https://www.mdpi.com/2073-4409/12/12/1639

Internet

https://www.mdpi.com/2073-4409/12/12/1639

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