Prognostic implication of IgG4 and IgG1-positive cell infiltration in the lung in patients with idiopathic interstitial pneumonia

Prognostic implication of IgG4 and IgG1-positive cell infiltration in the lung in patients with idiopathic interstitial pneumonia

Abstract Immunoglobulin (Ig) G4-positive cells are rarely observed in the lungs of patients with idiopathic interstitial pneumonias (IIPs). IgG1 may be more pathogenic than IgG4, with IgG4 having both pathogenic and protective roles in IgG4-related disease (IgG4-RD). However, the role of both IgG1 a...

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Main Authors: Masamichi Komatsu, Hiroshi Yamamoto, Takeshi Uehara, Yukihiro Kobayashi, Hironao Hozumi, Tomoyuki Fujisawa, Atsushi Miyamoto, Tomoo Kishaba, Fumihito Kunishima, Masaki Okamoto, Hideya Kitamura, Tae Iwasawa, Shoichiro Matsushita, Yasuhiro Terasaki, Shinobu Kunugi, Atsuhito Ushiki, Masanori Yasuo, Takafumi Suda, Masayuki Hanaoka
Format: Article
Language:English
Published: Nature Portfolio 2022-06-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-022-13333-8

Internet

https://doi.org/10.1038/s41598-022-13333-8

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