Prognostic implication of IgG4 and IgG1-positive cell infiltration in the lung in patients with idiopathic interstitial pneumonia
Abstract Immunoglobulin (Ig) G4-positive cells are rarely observed in the lungs of patients with idiopathic interstitial pneumonias (IIPs). IgG1 may be more pathogenic than IgG4, with IgG4 having both pathogenic and protective roles in IgG4-related disease (IgG4-RD). However, the role of both IgG1 a...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2022-06-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-022-13333-8 |
| _version_ | 1828724974854078464 |
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| author | Masamichi Komatsu Hiroshi Yamamoto Takeshi Uehara Yukihiro Kobayashi Hironao Hozumi Tomoyuki Fujisawa Atsushi Miyamoto Tomoo Kishaba Fumihito Kunishima Masaki Okamoto Hideya Kitamura Tae Iwasawa Shoichiro Matsushita Yasuhiro Terasaki Shinobu Kunugi Atsuhito Ushiki Masanori Yasuo Takafumi Suda Masayuki Hanaoka |
| author_facet | Masamichi Komatsu Hiroshi Yamamoto Takeshi Uehara Yukihiro Kobayashi Hironao Hozumi Tomoyuki Fujisawa Atsushi Miyamoto Tomoo Kishaba Fumihito Kunishima Masaki Okamoto Hideya Kitamura Tae Iwasawa Shoichiro Matsushita Yasuhiro Terasaki Shinobu Kunugi Atsuhito Ushiki Masanori Yasuo Takafumi Suda Masayuki Hanaoka |
| author_sort | Masamichi Komatsu |
| collection | DOAJ |
| description | Abstract Immunoglobulin (Ig) G4-positive cells are rarely observed in the lungs of patients with idiopathic interstitial pneumonias (IIPs). IgG1 may be more pathogenic than IgG4, with IgG4 having both pathogenic and protective roles in IgG4-related disease (IgG4-RD). However, the role of both IgG1 and IgG4 in IIPs remains unclear. We hypothesized that patients with IgG4-positive interstitial pneumonia manifest different clinical characteristics than patients with IgG4-RD. Herein, we identified the correlation of the degree of infiltration of IgG1- and IgG4-positive cells with IIP prognosis, using a Japanese nationwide cloud-based database. We included eighty-eight patients diagnosed with IIPs after multidisciplinary discussion, from April 2009 to March 2014. IgG4-positive cell infiltration was identified in 12/88 patients with IIPs and 8/41 patients with idiopathic pulmonary fibrosis (IPF). Additionally, 31/88 patients with IIPs and 19/41 patients with IPF were diagnosed as having IgG1-positive cell infiltration. IgG4-positive IIPs tended to have a better prognosis. Conversely, overall survival in cases with IgG1-positive IPF was significantly worse. IIPs were prevalent with IgG1- or IgG4-positive cell infiltration. IgG1-positive cell infiltration in IPF significantly correlated with a worse prognosis. Overall, evaluating the degree of IgG1-positive cell infiltration may be prognostically useful in cases of IPF. |
| first_indexed | 2024-04-12T13:19:08Z |
| format | Article |
| id | doaj.art-fec18f8e8aa64deba90d20daf3177fa1 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-04-12T13:19:08Z |
| publishDate | 2022-06-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-fec18f8e8aa64deba90d20daf3177fa12022-12-22T03:31:36ZengNature PortfolioScientific Reports2045-23222022-06-0112111010.1038/s41598-022-13333-8Prognostic implication of IgG4 and IgG1-positive cell infiltration in the lung in patients with idiopathic interstitial pneumoniaMasamichi Komatsu0Hiroshi Yamamoto1Takeshi Uehara2Yukihiro Kobayashi3Hironao Hozumi4Tomoyuki Fujisawa5Atsushi Miyamoto6Tomoo Kishaba7Fumihito Kunishima8Masaki Okamoto9Hideya Kitamura10Tae Iwasawa11Shoichiro Matsushita12Yasuhiro Terasaki13Shinobu Kunugi14Atsuhito Ushiki15Masanori Yasuo16Takafumi Suda17Masayuki Hanaoka18First Department of Internal Medicine, Shinshu University School of MedicineFirst Department of Internal Medicine, Shinshu University School of MedicineDepartment of Laboratory Medicine, Shinshu University School of MedicineDepartment of Laboratory Medicine, Shinshu University School of MedicineSecond Division, Department of Internal Medicine, Hamamatsu University School of MedicineSecond Division, Department of Internal Medicine, Hamamatsu University School of MedicineDepartment of Respiratory Medicine, Respiratory Center, Toranomon HospitalDepartment of Respiratory Medicine, Okinawa Prefectural Chubu HospitalDivision of Pathology, Okinawa Prefectural Chubu HospitalDivision of Respirology, Neurology, and Rheumatology, Department of Internal Medicine, Kurume University School of MedicineDivision of Respiratory Medicine, Kanagawa Cardiovascular and Respiratory CenterDepartment of Radiology, Kanagawa Cardiovascular and Respiratory CenterDepartment of Radiology, Yokohama City University HospitalDepartment of Analytic Human Pathology, Nippon Medical SchoolDepartment of Analytic Human Pathology, Nippon Medical SchoolFirst Department of Internal Medicine, Shinshu University School of MedicineFirst Department of Internal Medicine, Shinshu University School of MedicineSecond Division, Department of Internal Medicine, Hamamatsu University School of MedicineFirst Department of Internal Medicine, Shinshu University School of MedicineAbstract Immunoglobulin (Ig) G4-positive cells are rarely observed in the lungs of patients with idiopathic interstitial pneumonias (IIPs). IgG1 may be more pathogenic than IgG4, with IgG4 having both pathogenic and protective roles in IgG4-related disease (IgG4-RD). However, the role of both IgG1 and IgG4 in IIPs remains unclear. We hypothesized that patients with IgG4-positive interstitial pneumonia manifest different clinical characteristics than patients with IgG4-RD. Herein, we identified the correlation of the degree of infiltration of IgG1- and IgG4-positive cells with IIP prognosis, using a Japanese nationwide cloud-based database. We included eighty-eight patients diagnosed with IIPs after multidisciplinary discussion, from April 2009 to March 2014. IgG4-positive cell infiltration was identified in 12/88 patients with IIPs and 8/41 patients with idiopathic pulmonary fibrosis (IPF). Additionally, 31/88 patients with IIPs and 19/41 patients with IPF were diagnosed as having IgG1-positive cell infiltration. IgG4-positive IIPs tended to have a better prognosis. Conversely, overall survival in cases with IgG1-positive IPF was significantly worse. IIPs were prevalent with IgG1- or IgG4-positive cell infiltration. IgG1-positive cell infiltration in IPF significantly correlated with a worse prognosis. Overall, evaluating the degree of IgG1-positive cell infiltration may be prognostically useful in cases of IPF.https://doi.org/10.1038/s41598-022-13333-8 |
| spellingShingle | Masamichi Komatsu Hiroshi Yamamoto Takeshi Uehara Yukihiro Kobayashi Hironao Hozumi Tomoyuki Fujisawa Atsushi Miyamoto Tomoo Kishaba Fumihito Kunishima Masaki Okamoto Hideya Kitamura Tae Iwasawa Shoichiro Matsushita Yasuhiro Terasaki Shinobu Kunugi Atsuhito Ushiki Masanori Yasuo Takafumi Suda Masayuki Hanaoka Prognostic implication of IgG4 and IgG1-positive cell infiltration in the lung in patients with idiopathic interstitial pneumonia Scientific Reports |
| title | Prognostic implication of IgG4 and IgG1-positive cell infiltration in the lung in patients with idiopathic interstitial pneumonia |
| title_full | Prognostic implication of IgG4 and IgG1-positive cell infiltration in the lung in patients with idiopathic interstitial pneumonia |
| title_fullStr | Prognostic implication of IgG4 and IgG1-positive cell infiltration in the lung in patients with idiopathic interstitial pneumonia |
| title_full_unstemmed | Prognostic implication of IgG4 and IgG1-positive cell infiltration in the lung in patients with idiopathic interstitial pneumonia |
| title_short | Prognostic implication of IgG4 and IgG1-positive cell infiltration in the lung in patients with idiopathic interstitial pneumonia |
| title_sort | prognostic implication of igg4 and igg1 positive cell infiltration in the lung in patients with idiopathic interstitial pneumonia |
| url | https://doi.org/10.1038/s41598-022-13333-8 |
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