Effects of Angiotensin-I-Converting Enzyme (ACE) Mutations Associated with Alzheimer’s Disease on Blood ACE Phenotype

Effects of Angiotensin-I-Converting Enzyme (ACE) Mutations Associated with Alzheimer’s Disease on Blood ACE Phenotype

Backgrounds. Our recent analysis of 1200+ existing missense ACE mutations revealed that 400+ mutations are damaging and led us to hypothesize that carriers of heterozygous loss-of-function (LoF) ACE mutations (which result in low ACE levels) could be at risk for the development of late-onset Alzheim...

全面介紹

書目詳細資料
Main Authors: Olga V. Kryukova, Igor O. Islanov, Elena V. Zaklyazminskaya, Dmitry O. Korostin, Vera A. Belova, Valery V. Cheranev, Zhanna A. Repinskaia, Svetlana A. Tonevitskaya, Pavel A. Petukhov, Steven M. Dudek, Olga A. Kost, Denis V. Rebrikov, Sergei M. Danilov
格式: Article
語言:English
出版: MDPI AG 2024-10-01
叢編:Biomedicines
主題:
angiotensin-I-converting enzyme
mutations
conformational changes
blood ACE
screening
Alzheimer’s disease
在線閱讀:https://www.mdpi.com/2227-9059/12/10/2410

因特網

https://www.mdpi.com/2227-9059/12/10/2410

相似書籍