Striking efficacy of a vaccine targeting TOP2A for triple-negative breast cancer immunoprevention

Striking efficacy of a vaccine targeting TOP2A for triple-negative breast cancer immunoprevention

Abstract Triple-negative breast cancer (TNBC) is an aggressive subtype of breast cancer that has a poor prognosis. TOP2A is a key enzyme in DNA replication and is a therapeutic target for breast and other cancers. TOP2A-specific Th1-promoting epitopes with optimal binding affinity to MHC II were ide...

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Bibliographic Details
Main Authors: Sang Beom Lee, Jing Pan, Donghai Xiong, Katie Palen, Bryon Johnson, Ronald A. Lubet, Robert H. Shoemaker, Jeffrey E. Green, Romaine Ingrid Fernando, Shizuko Sei, Ming You, Yian Wang
Format: Article
Language:English
Published: Nature Portfolio 2023-10-01
Series:npj Precision Oncology
Online Access:https://doi.org/10.1038/s41698-023-00461-1

Internet

https://doi.org/10.1038/s41698-023-00461-1

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