Suppression of Platelet-Derived Growth Factor Receptor-Alpha Overcomes Resistance to Trastuzumab through STAT3-Dependent IL-6 Reduction in HER2-Positive Breast Cancer Cells

Suppression of Platelet-Derived Growth Factor Receptor-Alpha Overcomes Resistance to Trastuzumab through STAT3-Dependent IL-6 Reduction in HER2-Positive Breast Cancer Cells

Platelet-derived growth factor receptor (PDGFR) plays an essential role in the proliferation and invasion of malignant cancer cells. However, the functional role of PDGFR alpha (PDGFRA) in HER2-positive (HER2+) breast cancer has not been fully clarified yet. Thus, the objective of this study was to...

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Bibliographic Details
Main Authors: Sangmin Kim, Hyungjoo Kim, Yisun Jeong, Daeun You, Sun Young Yoon, Eunji Lo, Seok Jin Nam, Jeong Eon Lee, Seok Won Kim
Format: Article
Language:English
Published: MDPI AG 2023-02-01
Series:Biomedicines
Subjects:
PDGFRA
IL-6
trastuzumab resistance
HER2+ breast cancer
Online Access:https://www.mdpi.com/2227-9059/11/3/675

Internet

https://www.mdpi.com/2227-9059/11/3/675

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