The Insulin/IGF system in colorectal cancer development and resistance to therapy

The Insulin/IGF system in colorectal cancer development and resistance to therapy

The Insulin/Insulin-like growth factor (IGF) system is a major determinant in the pathogenesis and progression of colorectal cancer (CRC). Indeed, several components of this signaling network including Insulin, IGF-1, IGF-2, the IGF-Binding Proteins, the Insulin Receptor (IR), the IGF-1 Receptor (IG...

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Bibliographic Details
Main Authors: Paolo Giovanni Vigneri, Elena eTirrò, Maria Stella ePennisi, Michele eMassimino, Stefania eStella, Chiara eRomano, Livia eManzella
Format: Article
Language:English
Published: Frontiers Media S.A. 2015-10-01
Series:Frontiers in Oncology
Subjects:
Insulin
colorectal cancer
IGF
IGF receptor
Insulin receptor
insulin/IGF signaling
Online Access:http://journal.frontiersin.org/Journal/10.3389/fonc.2015.00230/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fonc.2015.00230/full

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