Loss-of-function N178T variant of the human P2Y4 receptor is associated with decreased severity of coronary artery disease and improved glucose homeostasis

Loss-of-function N178T variant of the human P2Y4 receptor is associated with decreased severity of coronary artery disease and improved glucose homeostasis

Human P2Y4 is a UTP receptor, while in mice it is activated by both ATP and UTP. P2Y4 knockout (KO) in mice protects against myocardial infarction and is characterized by increased adiponectin secretion by adipocytes, and decreased cardiac inflammation and permeability under ischemic conditions. The...

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Bibliographic Details
Main Authors: Michael Horckmans, Esteban Diaz Villamil, Céline Verdier, Henrik Laurell, Jean-Bernard Ruidavets, Lucas De Roeck, Guillaume Combes, Laurent O. Martinez, Didier Communi
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-12-01
Series:Frontiers in Pharmacology
Subjects:
P2Y receptor
cardioprotection
extracellular nucleotides
glucose homeostasis
cardiac ischemia
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2022.1049696/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2022.1049696/full

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