Alzheimer’s disease phospholipase C-gamma-2 (PLCG2) protective variant is a functional hypermorph

Alzheimer’s disease phospholipase C-gamma-2 (PLCG2) protective variant is a functional hypermorph

Abstract Background Recent Genome Wide Association Studies (GWAS) have identified novel rare coding variants in immune genes associated with late onset Alzheimer’s disease (LOAD). Amongst these, a polymorphism in phospholipase C-gamma 2 (PLCG2) P522R has been reported to be protective against LOAD....

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Bibliographic Details
Main Authors: Lorenza Magno, Christian B. Lessard, Marta Martins, Verena Lang, Pedro Cruz, Yasmine Asi, Matilda Katan, Jamie Bilsland, Tammaryn Lashley, Paramita Chakrabarty, Todd E. Golde, Paul J. Whiting
Format: Article
Language:English
Published: BMC 2019-02-01
Series:Alzheimer’s Research & Therapy
Subjects:
Neuroinflammation
Phospholipase C
Dementia
Immune response
Genetic variants
Online Access:http://link.springer.com/article/10.1186/s13195-019-0469-0

Internet

http://link.springer.com/article/10.1186/s13195-019-0469-0

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