A cookbook for DNase Hi-C
Abstract Background The Hi-C technique is widely employed to study the 3-dimensional chromatin architecture and to assemble genomes. The conventional in situ Hi-C protocol employs restriction enzymes to digest chromatin, which results in nonuniform genomic coverage. Using sequence-agnostic restricti...
Główni autorzy: | , , , , , , , , , , |
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Format: | Artykuł |
Język: | English |
Wydane: |
BMC
2021-03-01
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Seria: | Epigenetics & Chromatin |
Hasła przedmiotowe: | |
Dostęp online: | https://doi.org/10.1186/s13072-021-00389-5 |