A cookbook for DNase Hi-C

A cookbook for DNase Hi-C

Abstract Background The Hi-C technique is widely employed to study the 3-dimensional chromatin architecture and to assemble genomes. The conventional in situ Hi-C protocol employs restriction enzymes to digest chromatin, which results in nonuniform genomic coverage. Using sequence-agnostic restricti...

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Bibliographic Details
Main Authors: Maria Gridina, Evgeniy Mozheiko, Emil Valeev, Ludmila P. Nazarenko, Maria E. Lopatkina, Zhanna G. Markova, Maria I. Yablonskaya, Viktoria Yu Voinova, Nadezhda V. Shilova, Igor N. Lebedev, Veniamin Fishman
Format: Article
Language:English
Published: BMC 2021-03-01
Series:Epigenetics & Chromatin
Subjects:
DNAse I
Hi-C
Genome organization
Human peripheral blood
K562
LNCaP
Online Access:https://doi.org/10.1186/s13072-021-00389-5

Internet

https://doi.org/10.1186/s13072-021-00389-5

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