Adenovirus-Based Gene Therapy for Bone Regeneration: A Comparative Analysis of In Vivo and Ex Vivo <i>BMP2</i> Gene Delivery

Adenovirus-Based Gene Therapy for Bone Regeneration: A Comparative Analysis of In Vivo and Ex Vivo <i>BMP2</i> Gene Delivery

Adenovirus-mediated gene therapy is a promising tool in bone regenerative medicine. In this work, gene-activated matrices (GAMs) composed of (1) polylactide granules (PLA), which serve as a depot for genetic constructs or matrices for cell attachment, (2) a PRP-based fibrin clot, which is a source o...

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Bibliographic Details
Main Authors: Tatiana Borisovna Bukharova, Irina Alekseevna Nedorubova, Viktoria Olegovna Mokrousova, Anastasiia Yurevna Meglei, Viktoriia Pavlovna Basina, Andrey Anatolevich Nedorubov, Andrey Vyacheslavovich Vasilyev, Timofei Evgenevich Grigoriev, Yuriy Dmitrievich Zagoskin, Sergei Nicolaevich Chvalun, Sergey Ivanovich Kutsev, Dmitry Vadimovich Goldshtein
Format: Article
Language:English
Published: MDPI AG 2023-07-01
Series:Cells
Subjects:
gene therapy
adenoviral transduction
mesenchymal stem cells
polylactide granules
platelet rich plasma
bone regeneration
Online Access:https://www.mdpi.com/2073-4409/12/13/1762

Internet

https://www.mdpi.com/2073-4409/12/13/1762

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