Single-cell sequencing and tumorigenesis: improved understanding of tumor evolution and metastasis

Single-cell sequencing and tumorigenesis: improved understanding of tumor evolution and metastasis

Abstract Extensive genomic and transcriptomic heterogeneity in human cancer often negatively impacts treatment efficacy and survival, thus posing a significant ongoing challenge for modern treatment regimens. State-of-the-art DNA- and RNA-sequencing methods now provide high-resolution genomic and ge...

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Bibliographic Details
Main Authors: Darrell L. Ellsworth, Heather L. Blackburn, Craig D. Shriver, Shahrooz Rabizadeh, Patrick Soon-Shiong, Rachel E. Ellsworth
Format: Article
Language:English
Published: Wiley 2017-04-01
Series:Clinical and Translational Medicine
Subjects:
Single-cell sequencing
Whole-genome amplification
Cancer
Tumor heterogeneity
Cancer stem cells
Circulating tumor cells
Online Access:http://link.springer.com/article/10.1186/s40169-017-0145-6

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http://link.springer.com/article/10.1186/s40169-017-0145-6

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