2-(Piperidin-4-yl)acetamides as Potent Inhibitors of Soluble Epoxide Hydrolase with Anti-Inflammatory Activity

2-(Piperidin-4-yl)acetamides as Potent Inhibitors of Soluble Epoxide Hydrolase with Anti-Inflammatory Activity

The pharmacological inhibition of soluble epoxide hydrolase (sEH) has been suggested as a potential therapy for the treatment of pain and inflammatory diseases through the stabilization of endogenous epoxyeicosatrienoic acids. Numerous potent sEH inhibitors (sEHI) have been developed, however many c...

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Détails bibliographiques
Auteurs principaux: Juan Martín-López, Sandra Codony, Clara Bartra, Christophe Morisseau, María Isabel Loza, Coral Sanfeliu, Bruce D. Hammock, José Brea, Santiago Vázquez
Format: Article
Langue:English
Publié: MDPI AG 2021-12-01
Collection:Pharmaceuticals
Sujets:
amide
benzohomoadamantane
DMPK properties
piperidine
soluble epoxide hydrolase
Accès en ligne:https://www.mdpi.com/1424-8247/14/12/1323

Internet

https://www.mdpi.com/1424-8247/14/12/1323

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