Gene-Directed Enzyme Prodrug Therapy by Dendrimer-Like Mesoporous Silica Nanoparticles against Tumor Cells

Gene-Directed Enzyme Prodrug Therapy by Dendrimer-Like Mesoporous Silica Nanoparticles against Tumor Cells

We report herein a gene-directed enzyme prodrug therapy (GDEPT) system using gated mesoporous silica nanoparticles (MSNs) in an attempt to combine the reduction of side effects characteristic of GDEPT with improved pharmacokinetics promoted by gated MSNs. The system consists of the transfection of c...

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Bibliographic Details
Main Authors: Vicente Candela-Noguera, Gema Vivo-Llorca, Borja Díaz de Greñu, María Alfonso, Elena Aznar, Mar Orzáez, María Dolores Marcos, Félix Sancenón, Ramón Martínez-Máñez
Format: Article
Language:English
Published: MDPI AG 2021-05-01
Series:Nanomaterials
Subjects:
GDEPT
DMSNs
tumor treatment
drug delivery
Online Access:https://www.mdpi.com/2079-4991/11/5/1298

Internet

https://www.mdpi.com/2079-4991/11/5/1298

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