Effect of intra-hippocampal injection of human recombinant growth hormone on synaptic plasticity in the nucleus basalis magnocellularis-lesioned aged rats

Effect of intra-hippocampal injection of human recombinant growth hormone on synaptic plasticity in the nucleus basalis magnocellularis-lesioned aged rats

ABSTRACT In this study, we proposed that administration of hippocampal growth hormone in ageing animals with growth hormone deficiency can compensate long-term potentiation and synaptic plasticity in nucleus basalis magnocellularis (NBM)-lesioned rats. Aged male Wistar rats were randomly divided int...

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Bibliographic Details
Main Authors: Maryam Malek, Alireza Sarkaki, Saleh Zahedi-Asl, Ziba Rajaei, Yaghoob Farbood
Format: Article
Language:English
Published: Academia Brasileira de Neurologia (ABNEURO)
Series:Arquivos de Neuro-Psiquiatria
Subjects:
growth hormone
hippocampus
basal nucleus of Meynert
long-term potentiation
Alzheimer disease
cognition disorders
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2017000700477&lng=en&tlng=en

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http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2017000700477&lng=en&tlng=en

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