The GSK3 kinase and LZTR1 protein regulate the stability of Ras family proteins and the proliferation of pancreatic cancer cells

The GSK3 kinase and LZTR1 protein regulate the stability of Ras family proteins and the proliferation of pancreatic cancer cells

Ras family proteins are membrane-bound GTPases that control proliferation, survival, and motility. Many forms of cancers are driven by the acquisition of somatic mutations in a RAS gene. In pancreatic cancer (PC), more than 90% of tumors carry an activating mutation in KRAS. Mutations in components...

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Bibliographic Details
Main Authors: Chitra Palanivel, Neha Chaudhary, Parthasarathy Seshacharyulu, Jesse L. Cox, Ying Yan, Surinder K. Batra, Michel M. Ouellette
Format: Article
Language:English
Published: Elsevier 2022-03-01
Series:Neoplasia: An International Journal for Oncology Research
Subjects:
Pancreatic cancer
RAS
LZTR1
GSK3
Protein stability
Online Access:http://www.sciencedirect.com/science/article/pii/S1476558622000021

Internet

http://www.sciencedirect.com/science/article/pii/S1476558622000021

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