Mediator Kinase Phosphorylation of STAT1 S727 Promotes Growth of Neoplasms With JAK-STAT Activation

Mediator Kinase Phosphorylation of STAT1 S727 Promotes Growth of Neoplasms With JAK-STAT Activation

Constitutive JAK-STAT signaling drives the proliferation of most myeloproliferative neoplasms (MPN) and a subset of acute myeloid leukemia (AML), but persistence emerges with chronic exposure to JAK inhibitors. MPN and post-MPN AML are dependent on tyrosine phosphorylation of STATs, but the role of...

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Bibliographic Details
Main Authors: Ioana I. Nitulescu, Sara C. Meyer, Qiang Jeremy Wen, John D. Crispino, Madeleine E. Lemieux, Ross L. Levine, Henry E. Pelish, Matthew D. Shair
Format: Article
Language:English
Published: Elsevier 2017-12-01
Series:EBioMedicine
Subjects:
STAT1
MPN
CDK8
Kinase inhibitor
Leukemia
Super-enhancer
Cortistatin A
Ruxolitinib
Online Access:http://www.sciencedirect.com/science/article/pii/S2352396417304565

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http://www.sciencedirect.com/science/article/pii/S2352396417304565

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