Homogeneous antibody-drug conjugates: DAR 2 anti-HER2 obtained by conjugation on isolated light chain followed by mAb assembly

Homogeneous antibody-drug conjugates: DAR 2 anti-HER2 obtained by conjugation on isolated light chain followed by mAb assembly

Despite advances in medical care, cancer remains a major threat to human health. Antibody-drug conjugates (ADCs) are a promising targeted therapy to overcome adverse side effects to normal tissues. In this field, the current challenge is obtaining homogeneous preparations of conjugates, where a defi...

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Bibliographic Details
Main Authors: Mercè Farràs, Joan Miret, Marc Camps, Ramón Román, Óscar Martínez, Xavier Pujol, Stéphane Erb, Anthony Ehkirch, Sarah Cianferani, Antoni Casablancas, Jordi Joan Cairó
Format: Article
Language:English
Published: Taylor & Francis Group 2020-01-01
Series:mAbs
Subjects:
ADC
mAb
trastuzumab
assembly
disulfide bonds
Cys-based conjugation
Online Access:https://www.tandfonline.com/doi/10.1080/19420862.2019.1702262

Internet

https://www.tandfonline.com/doi/10.1080/19420862.2019.1702262

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