Structural investigation of Rett-inducing MeCP2 mutations

Structural investigation of Rett-inducing MeCP2 mutations

X-ray structure of methyl-CpG binding domain (MBD) of MeCP2, an intrinsically disordered protein (IDP) involved in Rett syndrome, offers a rational basis for defining the spatial distribution for most of the sites where mutations responsible of Rett syndrome, RTT, occur. We have ascribed pathogenici...

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Bibliographic Details
Main Authors: Ottavia Spiga, Simone Gardini, Nicole Rossi, Vittoria Cicaloni, Francesco Pettini, Neri Niccolai, Annalisa Santucci
Format: Article
Language:English
Published: KeAi Communications Co., Ltd. 2019-03-01
Series:Genes and Diseases
Online Access:http://www.sciencedirect.com/science/article/pii/S2352304218300692

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http://www.sciencedirect.com/science/article/pii/S2352304218300692

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