Piezo1-mediated fluid shear stress promotes OPG and inhibits RANKL via NOTCH3 in MLO-Y4 osteocytes

Piezo1-mediated fluid shear stress promotes OPG and inhibits RANKL via NOTCH3 in MLO-Y4 osteocytes

Piezo1, a mechanosensitive ion channel, participates in a variety of biological processes in maintaining bone homeostasis. As the most abundant cells in bones of the mammals, osteocytes play an essential role in bone formation, remodeling, and bone mass maintenance. Here, by exposing MLO-Y4 osteocyt...

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Bibliographic Details
Main Authors: Zhongcheng Liu, Yuchen Tang, Liangzhi He, Bin Geng, Fan Lu, Jinwen He, Qiong Yi, Xuening Liu, Kun Zhang, Lifu Wang, Yayi Xia, Jin Jiang
Format: Article
Language:English
Published: Taylor & Francis Group 2022-12-01
Series:Channels
Subjects:
Fluid shear stress
Piezo1
NOTCH3
RANKL
OPG
osteocyte
Online Access:https://www.tandfonline.com/doi/10.1080/19336950.2022.2085379

Internet

https://www.tandfonline.com/doi/10.1080/19336950.2022.2085379

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