In vitro evaluation of new terpenoid derivatives against Leishmania infantum and Leishmania braziliensis

In vitro evaluation of new terpenoid derivatives against Leishmania infantum and Leishmania braziliensis

The activity of five (1-5) abietane phenol derivatives against Leishmania infantum and Leishmania braziliensis was studied using promastigotes and axenic and intracellular amastigotes. Infectivity and cytotoxicity tests were performed with J774.2 macrophage cells using Glucantime as a reference drug...

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Bibliographic Details
Main Authors: Inmaculada Ramírez-Macías, Clotilde Marín, Rachid Chahboun, Francisco Olmo, Ibtisam Messouri, Oscar Huertas, María Jose Rosales, Ramón Gutierrez-Sánchez, Enrique Alvarez-Manzaneda, Manuel Sánchez-Moreno
Format: Article
Language:English
Published: Fundação Oswaldo Cruz (FIOCRUZ) 2012-05-01
Series:Memorias do Instituto Oswaldo Cruz
Subjects:
abietane phenol compounds
Leishmania infantum
Leishmania braziliensis
biological evaluation of activity
promastigote
amastigote forms
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762012000300012&lng=en&tlng=en

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http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762012000300012&lng=en&tlng=en

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