HIV-1 Tat-mediated microglial ferroptosis involves the miR-204–ACSL4 signaling axis

HIV-1 Tat-mediated microglial ferroptosis involves the miR-204–ACSL4 signaling axis

This study was focused on exploring the role of the HIV-1 Tat protein in mediating microglial ferroptosis. Exposure of mouse primary microglial cells (mPMs) to HIV-1 Tat protein resulted in induction of ferroptosis, which was characterized by increased expression of Acyl-CoA synthetase long-chain fa...

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Bibliographic Details
Main Authors: Muthukumar Kannan, Susmita Sil, Abiola Oladapo, Annadurai Thangaraj, Palsamy Periyasamy, Shilpa Buch
Format: Article
Language:English
Published: Elsevier 2023-06-01
Series:Redox Biology
Subjects:
Microglia
Ferroptosis
HIV-1 Tat
Neuroinflammation
Lipid oxidation
Online Access:http://www.sciencedirect.com/science/article/pii/S2213231723000903

Internet

http://www.sciencedirect.com/science/article/pii/S2213231723000903

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