PPARα Agonist, MHY3200, Alleviates Renal Inflammation during Aging via Regulating ROS/Akt/FoxO1 Signaling

PPARα Agonist, MHY3200, Alleviates Renal Inflammation during Aging via Regulating ROS/Akt/FoxO1 Signaling

PPARα is a ligand-dependent transcription factor and its activation is known to play an important role in cell defense through anti-inflammatory and antioxidant effects. MHY3200 (2-[4-(5-chlorobenzo[<i>d</i>]thiazol-2-yl)phenoxy]-2,2-difluoroacetic acid), a novel benzothiazole-derived pe...

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Bibliographic Details
Main Authors: Min Jo Kim, Dae Hyun Kim, EunJin Bang, Sang Gyun Noh, Pusoon Chun, Takako Yokozawa, Hyung Ryong Moon, Hae Young Chung
Format: Article
Language:English
Published: MDPI AG 2021-05-01
Series:Molecules
Subjects:
aging
MHY3200
ROS
Akt
NF-κB
inflammation
Online Access:https://www.mdpi.com/1420-3049/26/11/3197

Internet

https://www.mdpi.com/1420-3049/26/11/3197

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