Mutation in the kv3.3 voltage-gated potassium channel causing spinocerebellar ataxia 13 disrupts sound-localization mechanisms.

Mutation in the kv3.3 voltage-gated potassium channel causing spinocerebellar ataxia 13 disrupts sound-localization mechanisms.

Normal sound localization requires precise comparisons of sound timing and pressure levels between the two ears. The primary localization cues are interaural time differences, ITD, and interaural level differences, ILD. Voltage-gated potassium channels, including Kv3.3, are highly expressed in the a...

Full description

Bibliographic Details
Main Authors: John C Middlebrooks, Harry S Nick, S H Subramony, Joel Advincula, Raymond L Rosales, Lillian V Lee, Tetsuo Ashizawa, Michael F Waters
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3792041?pdf=render

Internet

http://europepmc.org/articles/PMC3792041?pdf=render

Similar Items