Black carrots fermented with Lactobacillus plantarum or Aspergillus oryzae prevent cognitive dysfunction by improving hippocampal insulin signalling in amyloid-β infused rats
We evaluated whether long-term consumption of black carrot (BC), black carrot fermented with Aspergillus oryzae (FBAO) and Lactobacillus plantarum (FBLP) extracts improved cognitive dysfunction and glucose homeostasis in type 2 diabetic rats with dementia. Male diabetic rats received hippocampal CA1...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2016-08-01
|
| Series: | Journal of Functional Foods |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S175646461630161X |
| _version_ | 1818950152508932096 |
|---|---|
| author | Sunmin Park Suna Kang Do-Youn Jeong Seong-Yeop Jeong Min Joo Kim |
| author_facet | Sunmin Park Suna Kang Do-Youn Jeong Seong-Yeop Jeong Min Joo Kim |
| author_sort | Sunmin Park |
| collection | DOAJ |
| description | We evaluated whether long-term consumption of black carrot (BC), black carrot fermented with Aspergillus oryzae (FBAO) and Lactobacillus plantarum (FBLP) extracts improved cognitive dysfunction and glucose homeostasis in type 2 diabetic rats with dementia. Male diabetic rats received hippocampal CA1 infusions of 3.6 nmol amyloid-β (25–35; AD) or amyloid-β (35–25, non-plaque forming; Normal) per day, for two weeks. AD rats received either 2% lyophilized BC, FBAO, and FBLP or dextrin (AD-CON) for 8 weeks. FBAO and FBLP, rich in aglycated anthocyanins, suppressed amyloid-β deposition in the hippocampus and potentiated insulin signalling, compared to the BC and the control. FBAO and FBLP had better cognitive function and less visceral fat mass than BC. FBLP most effectively improved both whole body and hepatic insulin resistance and first phase insulin secretion and insulin sensitivity in the hyperglycaemic state. Thus, FBLP and FBAO (1 g/kg bw/day; 0.5–1 mg cyanidin and malvidin aglycone/kg bw/day) may have the potent efficacy for improving cognitive function by preventing hippocampal insulin resistance. |
| first_indexed | 2024-12-20T09:14:03Z |
| format | Article |
| id | doaj.art-fee07d156233471eb7b140640014ad42 |
| institution | Directory Open Access Journal |
| issn | 1756-4646 |
| language | English |
| last_indexed | 2024-12-20T09:14:03Z |
| publishDate | 2016-08-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Functional Foods |
| spelling | doaj.art-fee07d156233471eb7b140640014ad422022-12-21T19:45:28ZengElsevierJournal of Functional Foods1756-46462016-08-0125354366Black carrots fermented with Lactobacillus plantarum or Aspergillus oryzae prevent cognitive dysfunction by improving hippocampal insulin signalling in amyloid-β infused ratsSunmin Park0Suna Kang1Do-Youn Jeong2Seong-Yeop Jeong3Min Joo Kim4Department of Food & Nutrition, Obesity/Diabetes Center, Hoseo University, Asan, South Korea; Corresponding author. Dept. of Food and Nutrition, Hoseo University, 165 Sechul-Ri, BaeBang-Yup, Asan-Si, ChungNam-Do 336-795, South Korea. Tel.: +82 41 540 5345; fax: +82 41 548 0670.Department of Food & Nutrition, Obesity/Diabetes Center, Hoseo University, Asan, South KoreaDepartment of R&D, Sungchang Research Center for Fermentation Microbes, Sunchang, South KoreaDepartment of R&D, Sungchang Research Center for Fermentation Microbes, Sunchang, South KoreaDepartment of Food & Nutrition, Obesity/Diabetes Center, Hoseo University, Asan, South KoreaWe evaluated whether long-term consumption of black carrot (BC), black carrot fermented with Aspergillus oryzae (FBAO) and Lactobacillus plantarum (FBLP) extracts improved cognitive dysfunction and glucose homeostasis in type 2 diabetic rats with dementia. Male diabetic rats received hippocampal CA1 infusions of 3.6 nmol amyloid-β (25–35; AD) or amyloid-β (35–25, non-plaque forming; Normal) per day, for two weeks. AD rats received either 2% lyophilized BC, FBAO, and FBLP or dextrin (AD-CON) for 8 weeks. FBAO and FBLP, rich in aglycated anthocyanins, suppressed amyloid-β deposition in the hippocampus and potentiated insulin signalling, compared to the BC and the control. FBAO and FBLP had better cognitive function and less visceral fat mass than BC. FBLP most effectively improved both whole body and hepatic insulin resistance and first phase insulin secretion and insulin sensitivity in the hyperglycaemic state. Thus, FBLP and FBAO (1 g/kg bw/day; 0.5–1 mg cyanidin and malvidin aglycone/kg bw/day) may have the potent efficacy for improving cognitive function by preventing hippocampal insulin resistance.http://www.sciencedirect.com/science/article/pii/S175646461630161XFermented black carrotAnthocyaninsCognitive dysfunctionEnergyGlucoseInsulin |
| spellingShingle | Sunmin Park Suna Kang Do-Youn Jeong Seong-Yeop Jeong Min Joo Kim Black carrots fermented with Lactobacillus plantarum or Aspergillus oryzae prevent cognitive dysfunction by improving hippocampal insulin signalling in amyloid-β infused rats Journal of Functional Foods Fermented black carrot Anthocyanins Cognitive dysfunction Energy Glucose Insulin |
| title | Black carrots fermented with Lactobacillus plantarum or Aspergillus oryzae prevent cognitive dysfunction by improving hippocampal insulin signalling in amyloid-β infused rats |
| title_full | Black carrots fermented with Lactobacillus plantarum or Aspergillus oryzae prevent cognitive dysfunction by improving hippocampal insulin signalling in amyloid-β infused rats |
| title_fullStr | Black carrots fermented with Lactobacillus plantarum or Aspergillus oryzae prevent cognitive dysfunction by improving hippocampal insulin signalling in amyloid-β infused rats |
| title_full_unstemmed | Black carrots fermented with Lactobacillus plantarum or Aspergillus oryzae prevent cognitive dysfunction by improving hippocampal insulin signalling in amyloid-β infused rats |
| title_short | Black carrots fermented with Lactobacillus plantarum or Aspergillus oryzae prevent cognitive dysfunction by improving hippocampal insulin signalling in amyloid-β infused rats |
| title_sort | black carrots fermented with lactobacillus plantarum or aspergillus oryzae prevent cognitive dysfunction by improving hippocampal insulin signalling in amyloid β infused rats |
| topic | Fermented black carrot Anthocyanins Cognitive dysfunction Energy Glucose Insulin |
| url | http://www.sciencedirect.com/science/article/pii/S175646461630161X |
| work_keys_str_mv | AT sunminpark blackcarrotsfermentedwithlactobacillusplantarumoraspergillusoryzaepreventcognitivedysfunctionbyimprovinghippocampalinsulinsignallinginamyloidbinfusedrats AT sunakang blackcarrotsfermentedwithlactobacillusplantarumoraspergillusoryzaepreventcognitivedysfunctionbyimprovinghippocampalinsulinsignallinginamyloidbinfusedrats AT doyounjeong blackcarrotsfermentedwithlactobacillusplantarumoraspergillusoryzaepreventcognitivedysfunctionbyimprovinghippocampalinsulinsignallinginamyloidbinfusedrats AT seongyeopjeong blackcarrotsfermentedwithlactobacillusplantarumoraspergillusoryzaepreventcognitivedysfunctionbyimprovinghippocampalinsulinsignallinginamyloidbinfusedrats AT minjookim blackcarrotsfermentedwithlactobacillusplantarumoraspergillusoryzaepreventcognitivedysfunctionbyimprovinghippocampalinsulinsignallinginamyloidbinfusedrats |