ABT-751 Induces Multiple Anticancer Effects in Urinary Bladder Urothelial Carcinoma-Derived Cells: Highlighting the Induction of Cytostasis through the Inhibition of <i>SKP2</i> at Both Transcriptional and Post-Translational Levels

ABT-751 Induces Multiple Anticancer Effects in Urinary Bladder Urothelial Carcinoma-Derived Cells: Highlighting the Induction of Cytostasis through the Inhibition of <i>SKP2</i> at Both Transcriptional and Post-Translational Levels

The objective was to investigate the anti-cancer effects and underlying molecular mechanisms of cytostasis which were activated by an anti-microtubule drug, ABT-751, in two urinary bladder urothelial carcinoma (UBUC)-derived cell lines, BFTC905 and J82, with distinct genetic backgrounds. A series of...

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Bibliographic Details
Main Authors: Seyedeh Zahra Dehghanian, Cheng-Tang Pan, Jasmine Marianne Lee, Yow-Ling Shiue
Format: Article
Language:English
Published: MDPI AG 2021-01-01
Series:International Journal of Molecular Sciences
Subjects:
ABT-751
cytostasis
<i>S-phase kinase associated protein 2</i>
AKT
cyclin-dependent kinase inhibitors
Online Access:https://www.mdpi.com/1422-0067/22/2/945

Internet

https://www.mdpi.com/1422-0067/22/2/945

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