Cp∗Rh/Ag catalyzed C–H activation/cyclization sequences of NH-sulfoximines to fused aza-polyheterocycles under gentle conditions
Disclosed herein is a novel Rh/Ag co-catalyzed SNH directed C–H activation and C–H/N–H bond functionalization protocol of free NH-sulfoximines with hypervalent iodonium ylides. With the aid of AgOTf, these C–H functionalization/cyclization sequences could be achieved at room temperature conditions....
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
KeAi Communications Co. Ltd.
2023-05-01
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| Series: | Green Synthesis and Catalysis |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2666554922000643 |
| Summary: | Disclosed herein is a novel Rh/Ag co-catalyzed SNH directed C–H activation and C–H/N–H bond functionalization protocol of free NH-sulfoximines with hypervalent iodonium ylides. With the aid of AgOTf, these C–H functionalization/cyclization sequences could be achieved at room temperature conditions. The reaction employed EtOH as a “green” solvent and low catalyst loading was required under an oxygen/water-insensitive condition. Under this mild protocol, a wide range of polyheterocyclic sulfoximines bearing fused saturated carbo(hetero)cycles are readily prepared, even toward a complex pharmaceutical Folliculin analog. |
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| ISSN: | 2666-5549 |