Elevated Tumor Lactate and Efflux in High-grade Prostate Cancer demonstrated by Hyperpolarized <sup>13</sup>C Magnetic Resonance Spectroscopy of Prostate Tissue Slice Cultures

Elevated Tumor Lactate and Efflux in High-grade Prostate Cancer demonstrated by Hyperpolarized <sup>13</sup>C Magnetic Resonance Spectroscopy of Prostate Tissue Slice Cultures

Non-invasive assessment of the biological aggressiveness of prostate cancer (PCa) is needed for men with localized disease. Hyperpolarized (HP) <sup>13</sup>C magnetic resonance (MR) spectroscopy is a powerful approach to image metabolism, specifically the conversion of HP [1-<sup>...

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Bibliographic Details
Main Authors: Renuka Sriram, Mark Van Criekinge, Justin DeLos Santos, Fayyaz Ahamed, Hecong Qin, Rosalie Nolley, Romelyn DeLos Santos, Z. Laura Tabatabai, Robert A. Bok, Kayvan R. Keshari, Daniel B. Vigneron, Donna M. Peehl, John Kurhanewicz
Format: Article
Language:English
Published: MDPI AG 2020-02-01
Series:Cancers
Subjects:
hyperpolarized <sup>13</sup>c magnetic resonance (hp <sup>13</sup>c mr)
dynamic nuclear polarization (dnp)
aerobic glycolysis
lactate dehydrogenase (ldh)
lactate efflux
prostate cancer
Online Access:https://www.mdpi.com/2072-6694/12/3/537

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https://www.mdpi.com/2072-6694/12/3/537

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