3K3A-Activated Protein C Protects the Blood-Brain Barrier and Neurons From Accelerated Ischemic Injury Caused by Pericyte Deficiency in Mice

3K3A-Activated Protein C Protects the Blood-Brain Barrier and Neurons From Accelerated Ischemic Injury Caused by Pericyte Deficiency in Mice

Pericytes, mural cells of brain capillaries, maintain the blood-brain barrier (BBB), regulate cerebral blood flow (CBF), and protect neurons against ischemic damage. To further investigate the role of pericytes in ischemia, we induced stroke by 45-min transient middle cerebral artery occlusion (tMCA...

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Bibliographic Details
Main Authors: Yaoming Wang, Kassandra Kisler, Angeliki Maria Nikolakopoulou, Jose A. Fernandez, John H. Griffin, Berislav V. Zlokovic
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-03-01
Series:Frontiers in Neuroscience
Subjects:
pericyte
ischemic stroke
blood-brain barrier
neurons
activated protein C
Online Access:https://www.frontiersin.org/articles/10.3389/fnins.2022.841916/full

Internet

https://www.frontiersin.org/articles/10.3389/fnins.2022.841916/full

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