Isolation and Identification of Isocoumarin Derivatives With Specific Inhibitory Activity Against Wnt Pathway and Metabolome Characterization of Lasiodiplodia venezuelensis

Isolation and Identification of Isocoumarin Derivatives With Specific Inhibitory Activity Against Wnt Pathway and Metabolome Characterization of Lasiodiplodia venezuelensis

The Wnt signaling pathway controls multiple events during embryonic development of multicellular animals and is carcinogenic when aberrantly activated in adults. Breast cancers are dependent on Wnt pathway overactivation mostly through dysregulation of pathway component protein expression, which nec...

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Bibliographic Details
Main Authors: Léonie Pellissier, Alexey Koval, Laurence Marcourt, Emerson Ferreira Queiroz, Nicole Lecoultre, Sara Leoni, Luis-Manuel Quiros-Guerrero, Morgane Barthélémy, Bastiaan L. Duivelshof, Davy Guillarme, Sébastien Tardy, Véronique Eparvier, Karl Perron, Jérôme Chave, Didier Stien, Katia Gindro, Vladimir Katanaev, Jean-Luc Wolfender
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-08-01
Series:Frontiers in Chemistry
Subjects:
natural product
Wnt pathway inhibitors
anticancer
Lasiodiplodia venezuelensis
endophytic fungi
bio-guided fractionation
Online Access:https://www.frontiersin.org/articles/10.3389/fchem.2021.664489/full

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https://www.frontiersin.org/articles/10.3389/fchem.2021.664489/full

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