Dual-targeted halofuginone hydrobromide nanocomplexes for promotion of macrophage repolarization and apoptosis of rheumatoid arthritis fibroblast-like synoviocytes in adjuvant-induced arthritis in rats

Dual-targeted halofuginone hydrobromide nanocomplexes for promotion of macrophage repolarization and apoptosis of rheumatoid arthritis fibroblast-like synoviocytes in adjuvant-induced arthritis in rats

Rheumatoid arthritis (RA) is a prevalent autoimmune disease characterized by chronic inflammation and excessive proliferation of the synovium. Currently, treatment options focus on either reducing inflammation or inhibiting synovial hyperplasia. However, these modalities are unsatisfactory in achiev...

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Bibliographic Details
Main Authors: Junping Zhu, Ye Lin, Gejing Li, Yini He, Zhaoli Su, Yuanyuan Tang, Ye Zhang, Qian Xu, Zhongliu Yao, Hua Zhou, Bin Liu, Xiong Cai
Format: Article
Language:English
Published: Elsevier 2024-11-01
Series:Journal of Pharmaceutical Analysis
Subjects:
Halofuginone hydrobromide
Rheumatoid arthritis
Nanocomplexes
Macrophage polarization
Rheumatoid arthritis fibroblast-like synoviocytes
Adjuvant-induced arthritis
Online Access:http://www.sciencedirect.com/science/article/pii/S2095177924000789

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http://www.sciencedirect.com/science/article/pii/S2095177924000789

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