Vaccination with live attenuated simian immunodeficiency virus causes dynamic changes in intestinal CD4+CCR5+ T cells

Eitemau Tebyg

• P16-38. Transient loss of intestinal CD4+CCR5+ lymphocytes following vaccination with live attenuated SIV indicates modification of T cell repertoire/memory
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• Heterologous protection elicited by candidate monomeric recombinant HIV-1 gp120 vaccine in the absence of cross neutralising antibodies in a macaque model
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• CD8+ lymphocytes do not mediate protection against acute superinfection 20 days after vaccination with a live attenuated simian immunodeficiency virus.
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• Complement-mediated virus infectivity neutralisation by HLA antibodies is associated with sterilising immunity to SIV challenge in the macaque model for HIV/AIDS.
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• Optimization of the doxycycline-dependent simian immunodeficiency virus through in vitro evolution
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