The degradation of poloxamer 188 in buffered formulation conditions

The degradation of poloxamer 188 in buffered formulation conditions

Abstract Poloxamer 188 (P188) as a non-ionic surfactant is used in proteinaceous formulations to prevent protein adsorption to hydrophobic surfaces and unfolding at interfaces, preventing the formation of aggregates and particles. Its chemical intactness is crucial to the stability of drug products...

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Bibliographic Details
Main Authors: Wei Chen, Siegfried Stolz, Vincent Wegbecher, Dixy Parakkattel, Christina Haeuser, Nuria Sancho Oltra, Ravuri S. K. Kishore, Steven Bond, Christian Bell, Robert Kopf
Format: Article
Language:English
Published: SpringerOpen 2022-03-01
Series:AAPS Open
Subjects:
Poloxamer
Degradation
Chromatography
Pharmaceutically relevant conditions
Degradants characterization
LC-MS
Online Access:https://doi.org/10.1186/s41120-022-00055-4

Internet

https://doi.org/10.1186/s41120-022-00055-4

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