Structural and biochemical rationale for enhanced spike protein fitness in delta and kappa SARS-CoV-2 variants

Structural and biochemical rationale for enhanced spike protein fitness in delta and kappa SARS-CoV-2 variants

Saville, Mannar et al. provide a structural basis for enhanced antibody evasion and ACE2 binding by the Delta SARS-CoV-2 spike protein. They further identify a head-to-head dimer-of-trimers cryoEM reconstruction unique to the Kappa variant spike.

Bibliographic Details
Main Authors: James W. Saville, Dhiraj Mannar, Xing Zhu, Shanti S. Srivastava, Alison M. Berezuk, Jean-Philippe Demers, Steven Zhou, Katharine S. Tuttle, Inna Sekirov, Andrew Kim, Wei Li, Dimiter S. Dimitrov, Sriram Subramaniam
Format: Article
Language:English
Published: Nature Portfolio 2022-02-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-022-28324-6

Internet

https://doi.org/10.1038/s41467-022-28324-6

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