Structural and biochemical rationale for enhanced spike protein fitness in delta and kappa SARS-CoV-2 variants
Saville, Mannar et al. provide a structural basis for enhanced antibody evasion and ACE2 binding by the Delta SARS-CoV-2 spike protein. They further identify a head-to-head dimer-of-trimers cryoEM reconstruction unique to the Kappa variant spike.
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2022-02-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-022-28324-6 |
| _version_ | 1818332027829616640 |
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| author | James W. Saville Dhiraj Mannar Xing Zhu Shanti S. Srivastava Alison M. Berezuk Jean-Philippe Demers Steven Zhou Katharine S. Tuttle Inna Sekirov Andrew Kim Wei Li Dimiter S. Dimitrov Sriram Subramaniam |
| author_facet | James W. Saville Dhiraj Mannar Xing Zhu Shanti S. Srivastava Alison M. Berezuk Jean-Philippe Demers Steven Zhou Katharine S. Tuttle Inna Sekirov Andrew Kim Wei Li Dimiter S. Dimitrov Sriram Subramaniam |
| author_sort | James W. Saville |
| collection | DOAJ |
| description | Saville, Mannar et al. provide a structural basis for enhanced antibody evasion and ACE2 binding by the Delta SARS-CoV-2 spike protein. They further identify a head-to-head dimer-of-trimers cryoEM reconstruction unique to the Kappa variant spike. |
| first_indexed | 2024-12-13T13:29:13Z |
| format | Article |
| id | doaj.art-feef3d51eb6145eeb9cb3f29799a3060 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-13T13:29:13Z |
| publishDate | 2022-02-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-feef3d51eb6145eeb9cb3f29799a30602022-12-21T23:44:13ZengNature PortfolioNature Communications2041-17232022-02-0113111010.1038/s41467-022-28324-6Structural and biochemical rationale for enhanced spike protein fitness in delta and kappa SARS-CoV-2 variantsJames W. Saville0Dhiraj Mannar1Xing Zhu2Shanti S. Srivastava3Alison M. Berezuk4Jean-Philippe Demers5Steven Zhou6Katharine S. Tuttle7Inna Sekirov8Andrew Kim9Wei Li10Dimiter S. Dimitrov11Sriram Subramaniam12Department of Biochemistry and Molecular Biology, University of British ColumbiaDepartment of Biochemistry and Molecular Biology, University of British ColumbiaDepartment of Biochemistry and Molecular Biology, University of British ColumbiaDepartment of Biochemistry and Molecular Biology, University of British ColumbiaDepartment of Biochemistry and Molecular Biology, University of British ColumbiaDepartment of Biochemistry and Molecular Biology, University of British ColumbiaDepartment of Biochemistry and Molecular Biology, University of British ColumbiaDepartment of Biochemistry and Molecular Biology, University of British ColumbiaBC Centre for Disease ControlCenter for Antibody Therapeutics, Division of Infectious Diseases, Department of Medicine, University of Pittsburgh School of MedicineCenter for Antibody Therapeutics, Division of Infectious Diseases, Department of Medicine, University of Pittsburgh School of MedicineCenter for Antibody Therapeutics, Division of Infectious Diseases, Department of Medicine, University of Pittsburgh School of MedicineDepartment of Biochemistry and Molecular Biology, University of British ColumbiaSaville, Mannar et al. provide a structural basis for enhanced antibody evasion and ACE2 binding by the Delta SARS-CoV-2 spike protein. They further identify a head-to-head dimer-of-trimers cryoEM reconstruction unique to the Kappa variant spike.https://doi.org/10.1038/s41467-022-28324-6 |
| spellingShingle | James W. Saville Dhiraj Mannar Xing Zhu Shanti S. Srivastava Alison M. Berezuk Jean-Philippe Demers Steven Zhou Katharine S. Tuttle Inna Sekirov Andrew Kim Wei Li Dimiter S. Dimitrov Sriram Subramaniam Structural and biochemical rationale for enhanced spike protein fitness in delta and kappa SARS-CoV-2 variants Nature Communications |
| title | Structural and biochemical rationale for enhanced spike protein fitness in delta and kappa SARS-CoV-2 variants |
| title_full | Structural and biochemical rationale for enhanced spike protein fitness in delta and kappa SARS-CoV-2 variants |
| title_fullStr | Structural and biochemical rationale for enhanced spike protein fitness in delta and kappa SARS-CoV-2 variants |
| title_full_unstemmed | Structural and biochemical rationale for enhanced spike protein fitness in delta and kappa SARS-CoV-2 variants |
| title_short | Structural and biochemical rationale for enhanced spike protein fitness in delta and kappa SARS-CoV-2 variants |
| title_sort | structural and biochemical rationale for enhanced spike protein fitness in delta and kappa sars cov 2 variants |
| url | https://doi.org/10.1038/s41467-022-28324-6 |
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