CircCD44 plays oncogenic roles in triple-negative breast cancer by modulating the miR-502–5p/KRAS and IGF2BP2/Myc axes

CircCD44 plays oncogenic roles in triple-negative breast cancer by modulating the miR-502–5p/KRAS and IGF2BP2/Myc axes

Abstract Background Emerging studies have revealed the potent functions of circRNAs in breast cancer tumorigenesis. However, the biogenesis, biofunction and mechanism of circRNAs in triple-negative breast cancer (TNBC) are largely unknown. Methods High-throughput RNA sequencing was applied to identi...

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Bibliographic Details
Main Authors: Jie Li, Xinya Gao, Zhanqiang Zhang, Yuanhui Lai, Xunxun Lin, Bo Lin, Maoguang Ma, Xiaoli Liang, Xixi Li, Weiming Lv, Ying Lin, Nu Zhang
Format: Article
Language:English
Published: BMC 2021-10-01
Series:Molecular Cancer
Subjects:
circRNAs
TNBC
circCD44
KRAS
MYC
IGF2BP2
Online Access:https://doi.org/10.1186/s12943-021-01444-1

Internet

https://doi.org/10.1186/s12943-021-01444-1

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