Dystonia-causing mutant torsinA inhibits cell adhesion and neurite extension through interference with cytoskeletal dynamics

Dystonia-causing mutant torsinA inhibits cell adhesion and neurite extension through interference with cytoskeletal dynamics

Early onset torsion dystonia is a movement disorder inherited as an autosomal dominant syndrome with reduced penetrance. Symptoms appear to result from altered neuronal circuitry within the brain with no evidence of neuronal loss. Most cases are caused by loss of a glutamic acid residue in the AAA+...

Full description

Bibliographic Details
Main Authors: Jeffrey W. Hewett, Juan Zeng, Brian P. Niland, D. Cristopher Bragg, Xandra O. Breakefield
Format: Article
Language:English
Published: Elsevier 2006-04-01
Series:Neurobiology of Disease
Subjects:
Intermediate filaments
Dystonia
DYT1
Vimentin
Fibroblasts
Cell adhesion
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996105002767

Internet

http://www.sciencedirect.com/science/article/pii/S0969996105002767

Similar Items