Bridging Computational Vaccinology and Vaccine Development Through Systematic Identification, Characterization, and Downselection of Conserved and Variable Circumsporozoite Protein CD4 T Cell Epitopes From Diverse Plasmodium falciparum Strains

Bridging Computational Vaccinology and Vaccine Development Through Systematic Identification, Characterization, and Downselection of Conserved and Variable Circumsporozoite Protein CD4 T Cell Epitopes From Diverse Plasmodium falciparum Strains

An effective malaria vaccine must prevent disease in a range of populations living in regions with vastly different transmission rates and protect against genetically-diverse Plasmodium falciparum (Pf) strains. The protective efficacy afforded by the currently licensed malaria vaccine, Mosquirix™, p...

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Bibliographic Details
Main Authors: Amy R. Noe, Frances E. Terry, Brian C. Schanen, Emily Sassano, Pooja Hindocha, Timothy W. Phares, Leonard Moise, Jayne M. Christen, Kenneth D. Tucker, Vinayaka Kotraiah, Donald R. Drake, William D. Martin, Anne S. De Groot, Gabriel M. Gutierrez
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-06-01
Series:Frontiers in Immunology
Subjects:
malaria
CSP
in silico epitope prediction
HLA-DR
multifunctional cytokine response
cross-strain
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.689920/full

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https://www.frontiersin.org/articles/10.3389/fimmu.2021.689920/full

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