Proteomic Profiling of Endothelial Cells Exposed to Mitomycin C: Key Proteins and Pathways Underlying Genotoxic Stress-Induced Endothelial Dysfunction

Proteomic Profiling of Endothelial Cells Exposed to Mitomycin C: Key Proteins and Pathways Underlying Genotoxic Stress-Induced Endothelial Dysfunction

Mitomycin C (MMC)-induced genotoxic stress can be considered to be a novel trigger of endothelial dysfunction and atherosclerosis—a leading cause of cardiovascular morbidity and mortality worldwide. Given the increasing genotoxic load on the human organism, the decryption of the molecular pathways u...

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Bibliographic Details
Main Authors: Maxim Sinitsky, Egor Repkin, Anna Sinitskaya, Victoria Markova, Daria Shishkova, Olga Barbarash
Format: Article
Language:English
Published: MDPI AG 2024-04-01
Series:International Journal of Molecular Sciences
Subjects:
mutagenesis
atherogenesis
endothelial disfunction
genotoxic stress
DNA damage
proteome
Online Access:https://www.mdpi.com/1422-0067/25/7/4044

Internet

https://www.mdpi.com/1422-0067/25/7/4044

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