Novel Pt(IV) prodrug self-assembled nanoparticles with enhanced blood circulation stability and improved antitumor capacity of oxaliplatin for cancer therapy

Novel Pt(IV) prodrug self-assembled nanoparticles with enhanced blood circulation stability and improved antitumor capacity of oxaliplatin for cancer therapy

AbstractPt(IV) compounds are regarded as prodrugs of active Pt(II) drugs (i.e. cisplatin, carboplatin, and oxaliplatin) and burgeoned as the most ideal candidates to substitute Pt(II) anticancer drugs with severe side effects. Nanoparticle drug delivery systems have been widely introduced to deliver...

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Bibliographic Details
Main Authors: Yuanlei Fu, Ying Kong, Xiangping Li, Dongfang Cheng, Yuqian Hou, Yan Li, Tongfang Li, Yani Xiao, Qiuyan Zhang, Rong Rong
Format: Article
Language:English
Published: Taylor & Francis Group 2023-12-01
Series:Drug Delivery
Subjects:
Platinum(IV) prodrug
self-assembled nanoparticles
pharmacokinetics
antitumor efficacy
oxaliplatin
Online Access:https://www.tandfonline.com/doi/10.1080/10717544.2023.2171158

Internet

https://www.tandfonline.com/doi/10.1080/10717544.2023.2171158

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