Biosynthesized Multivalent Lacritin Peptides Stimulate Exosome Production in Human Corneal Epithelium

Biosynthesized Multivalent Lacritin Peptides Stimulate Exosome Production in Human Corneal Epithelium

Lacripep is a therapeutic peptide derived from the human tear protein, Lacritin. Lacripep interacts with syndecan-1 and induces mitogenesis upon the removal of heparan sulfates (HS) that are attached at the extracellular domain of syndecan-1. The presence of HS is a prerequisite for the syndecan-1 c...

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Bibliographic Details
Main Authors: Changrim Lee, Maria C. Edman, Gordon W. Laurie, Sarah F. Hamm-Alvarez, J. Andrew MacKay
Format: Article
Language:English
Published: MDPI AG 2020-08-01
Series:International Journal of Molecular Sciences
Subjects:
lacritin
peptide biosynthesis
corneal epithelium
exosome
syndecan-1
elastin-like polypeptides
Online Access:https://www.mdpi.com/1422-0067/21/17/6157

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https://www.mdpi.com/1422-0067/21/17/6157

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