Endosome and Lysosome Membrane Properties Functionally Link to γ-Secretase in Live/Intact Cells

Endosome and Lysosome Membrane Properties Functionally Link to γ-Secretase in Live/Intact Cells

Our unique multiplexed imaging assays employing FRET biosensors have previously detected that γ-secretase processes APP C99 primarily in late endosomes and lysosomes in live/intact neurons. Moreover we have shown that Aβ peptides are enriched in the same subcellular loci. Given that γ-secretase is i...

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Bibliographic Details
Main Authors: Mei C. Q. Houser, Shane P. C. Mitchell, Priyanka Sinha, Brianna Lundin, Oksana Berezovska, Masato Maesako
Format: Article
Language:English
Published: MDPI AG 2023-02-01
Series:Sensors
Subjects:
γ-secretase
endosome and lysosome
membrane properties
Aβ
Online Access:https://www.mdpi.com/1424-8220/23/5/2651

Internet

https://www.mdpi.com/1424-8220/23/5/2651

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