Thermofluor-Based Optimization Strategy for the Stabilization of Recombinant Human Soluble Catechol-<i>O</i>-Methyltransferase

Thermofluor-Based Optimization Strategy for the Stabilization of Recombinant Human Soluble Catechol-<i>O</i>-Methyltransferase

Catechol-<i>O</i>-methyltransferase (COMT) has been involved in a number of medical conditions including catechol-estrogen-induced cancers and a great range of cardiovascular and neurodegenerative diseases such as Parkinson’s disease. Currently, Parkinson’s disease treatment relies on a...

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Bibliographic Details
Main Authors: Ana M. Gonçalves, Augusto Q. Pedro, Diana M. Oliveira, Adriana E. Oliveira, Marino F. A. Santos, Márcia A. S. Correia, João A. Queiroz, Eugénia Gallardo, Maria J. Romão, Luís A. Passarinha
Format: Article
Language:English
Published: MDPI AG 2022-10-01
Series:International Journal of Molecular Sciences
Subjects:
protein activity
protein stability
soluble catechol-<i>O</i>-methyltransferase (SCOMT)
thermal shift assay (TSA)
Online Access:https://www.mdpi.com/1422-0067/23/20/12298

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https://www.mdpi.com/1422-0067/23/20/12298

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