A Bibenzyl Component Moscatilin Mitigates Glycation-Mediated Damages in an SH-SY5Y Cell Model of Neurodegenerative Diseases through AMPK Activation and RAGE/NF-<i>κ</i>B Pathway Suppression

A Bibenzyl Component Moscatilin Mitigates Glycation-Mediated Damages in an SH-SY5Y Cell Model of Neurodegenerative Diseases through AMPK Activation and RAGE/NF-<i>κ</i>B Pathway Suppression

Moscatilin can protect rat pheochromocytoma cells against methylglyoxal-induced damage. Elimination of the effect of advanced glycation end-products (AGEs) but activation of AMP-activated protein kinase (AMPK) are the potential therapeutic targets for the neurodegenerative diseases. Our study aimed...

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Bibliographic Details
Main Authors: Mei Chou Lai, Wayne Young Liu, Shorong-Shii Liou, I-Min Liu
Format: Article
Language:English
Published: MDPI AG 2020-10-01
Series:Molecules
Subjects:
AMP-activated protein kinase
neurodegenerative diseases
advanced glycation end-products
moscatilin
SH-SY5Y cells
Online Access:https://www.mdpi.com/1420-3049/25/19/4574

Internet

https://www.mdpi.com/1420-3049/25/19/4574

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