A Novel Multifunctional 5,6-Dimethoxy-Indanone-Chalcone-Carbamate Hybrids Alleviates Cognitive Decline in Alzheimer’s Disease by Dual Inhibition of Acetylcholinesterase and Inflammation

A Novel Multifunctional 5,6-Dimethoxy-Indanone-Chalcone-Carbamate Hybrids Alleviates Cognitive Decline in Alzheimer’s Disease by Dual Inhibition of Acetylcholinesterase and Inflammation

BackgroundsAlzheimer’s disease (AD) is a multifactorial neurodegenerative disease. The treatment of AD through multiple pathological targets may generate therapeutic efficacy better. The multifunctional molecules that simultaneously hit several pathological targets have been of great interest in the...

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Bibliographic Details
Main Authors: Chan Liu, Zhipei Sang, Hong Pan, Qin Wu, Yu Qiu, Jingshan Shi
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-07-01
Series:Frontiers in Aging Neuroscience
Subjects:
Alzheimer’s disease
multi-target-directed ligands
acetylcholinesterase
amyloid-β
neuroinflammation
Online Access:https://www.frontiersin.org/articles/10.3389/fnagi.2022.922650/full

Internet

https://www.frontiersin.org/articles/10.3389/fnagi.2022.922650/full

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