NR4A1 inhibits the epithelial–mesenchymal transition of hepatic stellate cells: Involvement of TGF-β–Smad2/3/4–ZEB signaling

NR4A1 inhibits the epithelial–mesenchymal transition of hepatic stellate cells: Involvement of TGF-β–Smad2/3/4–ZEB signaling

This study aimed to examine whether nuclear receptor 4a1 (NR4A1) is involved in inhibiting hepatic stellate cell (HSC) activation and liver fibrosis through the epithelial–mesenchymal transition (EMT). HSC-T6 cells were divided into the control group, the acetaldehyde (200 μM, an EMT activator) grou...

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Bibliographic Details
Main Authors: Huang Qian, Xu Jingying, Ge Yanyan, Shi Yue, Wang Fei, Zhu Mingli
Format: Article
Language:English
Published: De Gruyter 2022-05-01
Series:Open Life Sciences
Subjects:
liver fibrosis
nuclear receptor 4a1
epithelial–mesenchymal transition
Online Access:https://doi.org/10.1515/biol-2022-0047

Internet

https://doi.org/10.1515/biol-2022-0047

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